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- 12-02-2023, 03:18
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Institute of Medicine, Board on Health Sciences Policy, Roundtable on Translating Genomic-Based Research for Health, "Genome-Based Therapeutics: Targeted Drug Discovery and Development: Workshop Summary"
English | 2012 | pages: 90 | ISBN: 0309260248 | PDF | 5,3 mb
The number of new drug approvals has remained reasonably steady for the past 50 years at around 20 to 30 per year, while at the same time the total spending on health-related research and development has tripled since 1990. There are many suspected causes for this trend, including increases in regulatory barriers, the rising costs of scientific inquiry, a decrease in research and development efficiency, the downstream effects of patient expirations on investment, and the lack of production models that have successfully incorporated new technology. Regardless, this trajectory is not economically sustainable for the businesses involved, and, in response, many companies are turning toward collaborative models of drug development, whether with other industrial firms, academia, or government. Introducing greater efficiency and knowledge into these new models and aligning incentives among participants may help to reverse the trends highlighted above, while producing more effective drugs in the process.
Genome-Based Therapeutics explains that new technologies have the potential to open up avenues of development and to identify new drug targets to pursue. Specifically, improved validation of gene-disease associations through genomics research has the potential to revolutionize drug production and lower development costs. Genetic information has helped developers by increasing their understanding of the mechanisms of disease as well as individual patients' reactions to their medications. There is a need to identify the success factors for the various models that are being developed, whether they are industry-led, academia-led, or collaborations between the two.
Genome-Based Therapeutics summarizes a workshop that was held on March 21, 2012, titled New Paradigms in Drug Discovery: How Genomic Data Are Being Used to Revolutionize the Drug Discovery and Development Process. At this workshop the goal was to examine the general approaches being used to apply successes achieved so far, and the challenges ahead.
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- 12-02-2023, 03:17
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- voska89
. 50MINUTES, "Generation Y in Business: Tips for building strong relationships between generations "
English | ISBN: 2806289203 | 2017 | 35 pages | EPUB | 2 MB
Ready to take your business to the next level? Find out everything you need to know about Generation Y in the workplace with this practical guide.
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- 12-02-2023, 03:16
- 124
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Gears and God: Technocratic Fiction, Faith, and Empire in Mark Twain's America By Nathaniel Williams
2018 | 224 Pages | ISBN: 0817319840 | PDF | 3 MB
A revealing study of the connections between nineteenth-century technological fiction and American religious faith. In Gears and God: Technocratic Fiction, Faith, and Empire in Mark Twain's America, Nathaniel Williams analyzes the genre of technology-themed exploration novels-dime novel adventure stories featuring steam-powered and electrified robots, airships, and submersibles. This genre proliferated during the same cultural moment when evolutionary science was dismantling Americans' prevailing, biblically based understanding of human history. While their heyday occurred in the late 1800s, technocratic adventure novels like Twain's A Connecticut Yankee in King Arthur's Court inspired later fiction about science and technology. Similar to the science fiction Descriptionlines of writers like Jules Verne and H. Rider Haggard, and anticipating the adventures of Tom Swift some decades later, these novels feature Americans using technology to visit and seize control of remote locales, a trait that has led many scholars to view them primarily as protoimperialist narratives. Their legacy, however, is more complicated. As they grew in popularity, such works became as concerned with the preservation of a fraught Anglo-Protestant American identity as they were with spreading that identity across the globe. Many of these novels frequently assert the Bible's authority as a historical source. Collectively, such stories popularized the notion that technology and travel might essentially "prove" the Bible's veracity-a message that continues to be deployed in contemporary debates over intelligent design, the teaching of evolution in public schools, and in reality TV shows that seek historical evidence for biblical events. Williams argues that these fictions performed significant cultural work, and he consolidates evidence from the novels themselves, as well as news articles, sermons, and other sources of the era, outlining and mapping the development of technocratic fiction.
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- Книги
- 12-02-2023, 03:15
- 124
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- voska89
Fully Accredited Foundation Level Acupressure Diploma Course: Learn Easy & Effective Acupressure Techniques in this Full Diploma Course by Karen E Wells
English | 2018 | ISBN: N/A | ASIN: B079CKH66Y | 95 pages | EPUB | 0.90 Mb
Our Online Professional Foundation Level Acupressure Training Course is an in-depth self-study course providing you with an abundance of information regarding the health benefits of acupressure and this will form the solid foundations of practice.
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- 12-02-2023, 03:14
- 120
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- voska89
Shu-Mei Huang, "Frontiers of Memory in the Asia-Pacific: Difficult Heritage and the Transnational Politics of Postcolonial Nationalism"
English | ISBN: 9888754149 | 2023 | 272 pages | PDF | 11 MB
New directions for comparative research into "difficult heritage" as a concept.
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- 12-02-2023, 03:13
- 136
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- voska89
Russell M. Lawson, "Frontier Naturalist: Jean Louis Berlandier and the Exploration of Northern Mexico and Texas"
English | ISBN: 0826352170 | 2012 | 288 pages | PDF | 3 MB
This is a true story of discovery and discoverers in what was the northern frontier region of Mexico in the years before the Mexican War. In 1826, when the story begins, the region was claimed by both Mexico and the United States. Neither country knew much about the lands crossed by such rivers as the Guadalupe, Brazos, Nueces, Trinity, and Rio Grande. Jean Louis Berlandier, a French naturalist, was part of a team sent out by the Mexican Boundary Commission to explore the area. His role was to collect specimens of flora and fauna and to record detailed observations of the landscapes and peoples through which the exploring party traveled. His observations, including sketches and paintings of plants, landmarks, and American Indians, were the first compendium of scientific observations of the region to be collected and eventually published.
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- 12-02-2023, 03:12
- 150
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Meryem Belkaïd, "From Outlaw to Rebel: Oppositional documentaries in Contemporary Algeria "
English | ISBN: 3031191560 | 2023 | 155 pages | PDF | 3 MB
This book analyzes the rise of socially and politically engaged Algerian documentaries, created in the period immediately following the end of the Algerian civil war (1991-1999). It uses case studies to highlight the works of four Algerian filmmakers, and devotes a chapter to each: Malek Bensmaïl, Hassen Ferhani, Djamel Kerkar, and Karim Sayad. The book makes visible productions that have been overlooked not only in distribution circuits but also within academia, and examines the political significance and the esthetic power of some of the most influential Algerian documentaries produced since the 2000s.
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- 12-02-2023, 03:11
- 149
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- voska89
Eric Wilson, "From Chains to Change: One Man's Journey from God-Hater to God-Follower"
English | ISBN: 1954437129 | 2021 | 352 pages | EPUB | 3 MB
At twelve years old, his hatred of God took root.
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- 12-02-2023, 03:10
- 132
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Alexandra Catalano, "From Beer Bongs to Broccoli: The College Kid's Guide To Health and Wellness"
English | ISBN: 1478107294 | 2013 | 148 pages | EPUB | 2 MB
From Beer Bongs To Broccoli is a humorous no nonsense guide to finding health and wellness in a college setting. College is one of the most thrilling times of your life, so why not look and feel your best? It?s the one opportunity where you can experience a multitude of new things in a safe and supportive environment. While college provides the perfect setting to discover one?s self, many students find themselves experiencing excessive weight gain, low energy, poor skin, frequent illness, depression and insomnia. My intention for writing this book is to help students discover how to give their body the proper love and attention it desperately needs while having fun and experiencing new things. Readers will learn how to nourish themselves without counting calories, fad diets or extreme exercise regimes. Instead, I provide readers with a variety of different philosophies and theories to help them achieve optimal health and mental awareness. The most important thing one can learn from this book is to understand how to experience something, analyze how they feel and then determine whether or not their body responds well to it. There?s no better feeling in the world than living in harmony with your values and beliefs. Many tout college as ? the best time of your life.? So don?t waste it. Treat everyday as a gift. Use nutrition to become the best version of yourself. Touch the lives of others and always be caring and compassionate.
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- 12-02-2023, 03:09
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Cassandra Blanchard, "Fresh Pack of Smokes"
English | 2019 | ISBN: 0889713529 | EPUB | pages: 96 | 1.0 mb
"This night in Oppenheimer Park Dan asked me to shit-kick this chick in the face as she owed money and I said no because I didn't know who she was and I wasn't about to play with fire so he sat on the bench then stood up and did a flying kick twice to her chin and she convulsed and passed out he said he didn't want to spill blood because she hadHIV..."
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